VISI-ON-BRAIN develops bioengineered systems to support human cell differentiation and functional analysis in controlled environments. This includes microfluidic and compartmentalised chip designs, dynamic scaffolds with different geometries, and high-throughput stimulators and sensors for neuronal activity. The programme aims to provide robust tools for investigating neurodevelopmental processes and brain disorder mechanisms, supporting interdisciplinary training across engineering and life sciences.
The network advances in vitro models for brain development and disease, including hPSC-derived models for neurodevelopmental and neurodegenerative disorders, and organoid-based approaches. The work includes genetic modifications to enable specific differentiation and functional readouts, and analyses of neural network connectivity and neuro-immune interactions relevant to selected disorders.
VISI-ON-BRAIN aims to establish tools to study immune–neural crosstalk using multi-compartment microfluidic systems connected to vasculature-like perfusion and blood–brain barrier components. The programme includes proof-of-concept testing with immune cell-derived factors and comparisons to relevant molecular profiles, supporting research into mechanisms and potential stratification concepts.
VISI-ON-BRAIN develops in silico models that integrate high-throughput data, multi-omics and functional readouts, including links between in vitro measures and EEG data. The programme includes an AI chatbot concept to improve neural differentiation protocols, and computational approaches connecting cellular-level models with macro-level observables in a transparent, testable way.
VISI-ON-BRAIN is designed to deliver impact across training, science, and longer-term innovation capacity. The network trains 15 doctoral candidates through interdisciplinary research, structured training and cross-sector experience, with secondments intended to expose all DCs to both academic and industrial settings.
Scientifically, the project develops and integrates bioengineering, in vitro and in silico approaches to generate new tools for studying brain disorders and to improve reproducibility and functional analysis. The programme also includes a dissemination and exploitation work package that supports responsible communication to different stakeholder groups and provides a framework for identifying exploitable results and protection measures when relevant.
VISI-ON-BRAIN is motivated by the need to develop alternative, human-focused approaches for brain disorder research. The project combines human cell-based in vitro systems with in silico modelling to study mechanisms at multiple levels and to support data integration and interpretation. The consortium focuses on developing robust tools, training researchers in responsible methods, and communicating results with appropriate caveats, emphasising transparent reporting, governance, and stewardship of data and outputs.
